WTAP

Across TCGA pan-cancer cohorts, WTAP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WTAP data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WTAP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WTAP expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where WTAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.590	0.917	.004	31	view →
LUAD	OS	Tertile	II,III,IV	0.838	0.426	.032	11	view →
LSCC	DFS	Quartile	II,III,IV	0.846	0.417	.039	4	view →
GBM	DFS	Quartile	All	0.287	0.521	.037	2	view →
CCRCC	DFS	Quartile	All	0.666	1.000	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WTAP–HNSC (DFS)

Open the HNSC breakdown →