Across TCGA patient cohorts, WT1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WT1-associated genes across cancer lineages are HIF1A, ARFGEF1, and RNU6-742P. Each is linked with WT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WT1-to-partner and partner-to-WT1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WT1→partner) and Y-score (partner→WT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HIF1A →	-1.035	-1.991	<.001	<.001	3	2
CCRCC	ARFGEF1 →	-0.491	-1.991	<.001	<.001	3	2
BRCA	RNU6-742P →	+1.065	+2.698	.003	.009	3	1
BRCA	CAPNS1P1 →	+0.240	+2.698	.006	.009	3	1
BRCA	HSD3BP3 →	+0.305	+2.698	.006	.009	3	1
BRCA	RNA5SP385 →	+1.040	+2.698	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,621 associations by consensus.

Exploration

WT1 survival (RNA) · tumor vs normal (RNA) · all WT1 data types