WSCD2

Across TCGA patient cohorts, WSCD2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WSCD2-associated genes across cancer lineages are 4E-BP1_pS65, Di-Ras3, and 4E-BP1. Each is linked with WSCD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WSCD2-to-partner and partner-to-WSCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by WSCD2-low versus WSCD2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WSCD2→partner) and Y-score (partner→WSCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1_pS65 →	+0.167	+3.584	.008	.002	3	2
UCEC	Di-Ras3 →	-0.128	-2.794	.004	.003	3	2
UCEC	4E-BP1 →	+0.294	+1.795	<.001	.007	3	2
COAD	C-Raf →	+0.144	+2.008	.015	.018	3	2
SKCM	GATA3 →	-0.147	-1.415	.040	.045	3	2
SKCM	IGFBP2 →	-0.463	-2.000	.015	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

4E-BP1_pS65 by WSCD2 expression — LUAD

Explore this box plot interactively →