WSCD2

Across TCGA pan-cancer cohorts, WSCD2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WSCD2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WSCD2 RNA is repressed in tumor relative to normal tissue. In most cancer types WSCD2 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and KIRC are the cancer types where WSCD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WSCD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−5.747	<.001	11	view →
KIRP	Female	All	−1.392	<.001	11	view →
KIRC	Male	All	−1.268	<.001	11	view →
COAD	Male	II,III,IV	−0.876	<.001	9	view →
UCEC	All	All	−2.227	<.001	6	view →
KICH	All	III,IV	−1.505	<.001	6	view →
STAD	All	All	−1.300	.001	6	view →
BRCA	Female	II,III,IV	−1.080	<.001	6	view →
PRAD	All	All	−0.992	<.001	2	view →
LUSC	All	All	+0.672	.005	2	view →
HNSC	All	III,IV	−0.315	.017	2	view →
CHOL	All	All	+0.091	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WSCD2–THCA

Open the THCA breakdown →