WSCD2

Across TCGA cell cohorts, WSCD2 mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WSCD2-associated genes across cancer lineages are PZP, CDCP2, and TAS2R7. Each is linked with WSCD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WSCD2-to-partner and partner-to-WSCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PZP grouped by WSCD2-low versus WSCD2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WSCD2→partner) and Y-score (partner→WSCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PZP →	+0.426	+3.479	<.001	.001	3	2
CNS	CDCP2 →	+0.023	+3.273	<.001	.006	3	2
BREAST	TAS2R7 →	+0.018	+3.963	<.001	.003	3	2
LARGE_INTESTINE	DHX40 →	+0.568	+3.364	.006	.002	3	2
LUNG_SCLC	PRAMEF15 →	+0.288	+3.232	.003	.008	3	1
UPPER_AERODIGESTIVE_TRACT	SPATS1 →	+0.067	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

PZP by WSCD2 expression — CNS

Explore this box plot interactively →