WSB2

Across TCGA patient cohorts, WSB2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WSB2-associated genes across cancer lineages are PDK1_pS241, Caspase-7-cleavedD198, and C-Raf. Each is linked with WSB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WSB2-to-partner and partner-to-WSB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by WSB2-low versus WSB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WSB2→partner) and Y-score (partner→WSB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.203	+2.335	.018	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.834	+3.459	.005	.005	3	1
UCEC	C-Raf →	+0.203	+2.321	.004	.035	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PDK1_pS241 by WSB2 expression — UCEC

Explore this box plot interactively →