WSB2

Across TCGA pan-cancer cohorts, WSB2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of WSB2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where WSB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WSB2 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

BLCA, LIHC, and KIRC are the cancer types where WSB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WSB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.520	.002	11	view →
LIHC	Female	II,III,IV	+1.466	<.001	9	view →
KIRC	Female	IV	+1.055	<.001	9	view →
THCA	Male	III,IV	−0.755	<.001	9	view →
KIRP	All	All	+0.396	.001	7	view →
UCEC	All	III,IV	+1.070	<.001	6	view →
BRCA	All	III,IV	+0.523	<.001	6	view →
LUSC	Female	All	+0.497	<.001	6	view →
COAD	All	All	−0.299	.001	6	view →
STAD	All	II,III,IV	+0.413	.008	5	view →
KICH	All	All	−0.639	<.001	4	view →
CHOL	Male	All	+2.338	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

WSB2–BLCA

Open the BLCA breakdown →