WSB2

Across TCGA cell cohorts, WSB2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WSB2-associated genes across cancer lineages are TMEM196, DEFB108B, and GSG1L2. Each is linked with WSB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WSB2-to-partner and partner-to-WSB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM196 grouped by WSB2-low versus WSB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WSB2→partner) and Y-score (partner→WSB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM196 →	+0.053	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB108B →	+0.163	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TMEM196 by WSB2 expression — BLOOD_Leukemia

Explore this box plot interactively →