WRAP73

Across TCGA patient cohorts, WRAP73 mutation is significantly associated with the RNA expression of many other genes, with 2,331 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WRAP73-associated genes across cancer lineages are INSL4, CCL5, and CCL4. Each is linked with WRAP73 in more than 2 cancer types. Because this analysis shows association rather than direction, both WRAP73-to-partner and partner-to-WRAP73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INSL4 grouped by WRAP73-low versus WRAP73-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRAP73→partner) and Y-score (partner→WRAP73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INSL4 →	+1.093	+2.674	<.001	.001	3	3
UCEC	CCL5 →	+0.999	+2.186	<.001	.001	3	2
UCEC	CCL4 →	+0.859	+2.021	<.001	<.001	3	2
COAD	SENP3-EIF4A1 →	+0.213	+3.392	<.001	.004	3	2
COAD	PTP4A3 →	-1.175	-3.449	<.001	.005	3	2
COAD	NHLRC1 →	-1.374	-3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,331 associations by consensus.

INSL4 by WRAP73 expression — COAD

Explore this box plot interactively →