WNT9A

Across TCGA pan-cancer cohorts, WNT9A Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated WNT9A data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher WNT9A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WNT9A expression acts as an unfavorable survival marker.

KIRC, BRCA, and READ are the cancer types where WNT9A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.133	0.805	<.001	42	view →
BRCA	OS	Median	All	0.146	0.924	<.001	36	view →
READ	DFS	Median	All	0.111	0.820	<.001	12	view →
LGG	OS	Median	All	0.300	0.830	.004	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
HNSC	DFS	Median	All	0.228	0.628	.033	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
COAD	OS	Median	All	0.598	0.872	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

WNT9A–KIRC (OS)

Open the KIRC breakdown →