WNT9A

Across TCGA pan-cancer cohorts, WNT9A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WNT9A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where WNT9A RNA is repressed in tumor relative to normal tissue. In most cancer types WNT9A is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and LUAD are the cancer types where WNT9A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT9A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.165	<.001	11	view →
BLCA	Male	All	−2.065	<.001	8	view →
LUAD	Female	All	−1.545	<.001	8	view →
THCA	Male	All	−0.660	<.001	8	view →
LUSC	All	II,III,IV	−1.279	<.001	6	view →
HNSC	All	All	+0.795	<.001	6	view →
KIRC	All	All	+0.473	<.001	6	view →
READ	All	All	−1.462	.001	5	view →
PAAD	All	All	+0.977	.008	4	view →
CHOL	All	All	+2.802	<.001	3	view →
UCEC	All	All	−1.322	.001	2	view →
BRCA	All	All	+0.254	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WNT9A–COAD

Open the COAD breakdown →