WNT9A

Across TCGA cell cohorts, WNT9A mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNT9A-associated genes across cancer lineages are MMP26, MAGEB4, and STRA8. Each is linked with WNT9A in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT9A-to-partner and partner-to-WNT9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by WNT9A-low versus WNT9A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT9A→partner) and Y-score (partner→WNT9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP26 →	+0.020	+5.022	<.001	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.126	+4.930	<.001	.001	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MINAR2 →	+0.053	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MMP26 by WNT9A expression — SKIN

Explore this box plot interactively →