WNT8B

Across TCGA patient cohorts, WNT8B mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT8B-associated genes across cancer lineages are MIR6129, PRR20A, and RNU6-741P. Each is linked with WNT8B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT8B-to-partner and partner-to-WNT8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6129 grouped by WNT8B-low versus WNT8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT8B→partner) and Y-score (partner→WNT8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6129 →	+0.441	+2.818	.001	.005	3	2
BRCA	PRR20A →	+0.024	+8.471	<.001	.005	3	2
SKCM	RNU6-741P →	+0.135	+3.990	<.001	.009	3	2
UCEC	TRAJ11 →	+0.615	+3.135	.003	.002	3	2
BRCA	LRRC6P1 →	+0.049	+8.055	<.001	.007	3	1
SKCM	LINC02439 →	+0.077	+3.990	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

MIR6129 by WNT8B expression — UCEC

Explore this box plot interactively →