WNT8B

Across TCGA cell cohorts, WNT8B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WNT8B-associated genes across cancer lineages are LRRC3C, SCGB3A2, and OR8D4. Each is linked with WNT8B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT8B-to-partner and partner-to-WNT8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by WNT8B-low versus WNT8B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT8B→partner) and Y-score (partner→WNT8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.352	+3.777	<.001	.007	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.172	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR8D4 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR6M1 →	+0.022	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

LRRC3C by WNT8B expression — LARGE_INTESTINE

Explore this box plot interactively →