WNT8A

Across TCGA pan-cancer cohorts, WNT8A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WNT8A data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher WNT8A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WNT8A expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

ESCA, LIHC, and UCEC are the cancer types where WNT8A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.164	0.702	.001	33	view →
LIHC	DFS	Median	All	0.055	0.556	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	6	view →
LUAD	OS	Median	II,III,IV	1.000	0.222	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WNT8A–ESCA (OS)

Open the ESCA breakdown →