WNT8A

Across TCGA pan-cancer cohorts, WNT8A RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of WNT8A’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where WNT8A RNA is repressed in tumor relative to normal tissue. In most cancer types WNT8A is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

UCEC, BRCA, and KIRC are the cancer types where WNT8A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT8A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	II,III,IV	−0.210	.031	6	view →
BRCA	All	III,IV	−0.085	<.001	6	view →
KIRC	All	All	+0.019	.001	4	view →
THCA	All	All	+0.044	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

WNT8A–UCEC

Open the UCEC breakdown →