WNT8A

Across TCGA pan-cancer cohorts, WNT8A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated WNT8A data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WNT8A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WNT8A expression acts as an unfavorable survival marker.

CCRCC and HNSC are the cancer types where WNT8A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.301	0.957	.002	15	view →
HNSC	DFS	Quartile	IV	0.538	0.800	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

WNT8A–CCRCC (DFS)

Open the CCRCC breakdown →