WNT8A

Across TCGA patient cohorts, WNT8A mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT8A-associated genes across cancer lineages are EGFR_pY1173, Acetyl-a-Tubulin-Lys40, and TFRC. Each is linked with WNT8A in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT8A-to-partner and partner-to-WNT8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by WNT8A-low versus WNT8A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT8A→partner) and Y-score (partner→WNT8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR_pY1173 →	+0.130	+2.820	.014	.035	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.708	+3.000	.024	.036	3	2
UCEC	TFRC →	+0.764	+3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.306	-3.321	.004	.009	3	1
UCEC	eIF4E →	+0.217	+3.183	.015	.009	3	1
UCEC	A-Raf_pS299 →	-0.151	-3.169	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1173 by WNT8A expression — SKCM

Explore this box plot interactively →