Across TCGA pan-cancer cohorts, WNT7B mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of WNT7B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where WNT7B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types WNT7B is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LSCC and LUAD are the cancer types where WNT7B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT7B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	+1.120	<.001	9	view →
LUAD	All	All	−0.338	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: WNT7B RNA expression & survival · all WNT7B data types