Across TCGA pan-cancer cohorts, WNT7B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated WNT7B data layer compared with 5 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher WNT7B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WNT7B expression acts as an unfavorable survival marker, although some lineages such as LGG and BLCA show a favorable association.
KIRC, UVM, and PAAD are the cancer types where WNT7B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.