Across TCGA patient cohorts, WNT7B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT7B-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK2, and N-Ras. Each is linked with WNT7B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT7B-to-partner and partner-to-WNT7B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT7B→partner) and Y-score (partner→WNT7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.169	-3.160	.006	.019	3	2
UCEC	JNK2 →	+0.293	+3.009	.003	.019	3	2
UCEC	N-Ras →	-0.139	-2.308	.020	.036	3	2
UCEC	ACC1 →	+0.630	+3.013	<.001	.018	3	1
UCEC	IGFBP2 →	-0.748	-3.000	.022	.036	3	1
UCEC	Ku80 →	+0.413	+3.013	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

WNT7B survival (RNA) · tumor vs normal (RNA) · all WNT7B data types