WNT7A

Across TCGA pan-cancer cohorts, WNT7A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WNT7A data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher WNT7A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WNT7A expression acts as an unfavorable survival marker.

BLCA, KIRP, and UCEC are the cancer types where WNT7A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.526	0.655	<.001	21	view →
KIRP	DFS	Median	All	0.181	0.768	.004	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WNT7A–BLCA (OS)

Open the BLCA breakdown →