WNT5A

Across TCGA pan-cancer cohorts, WNT5A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WNT5A data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WNT5A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated WNT5A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, STAD, and SARC are the cancer types where WNT5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.826	.005	36	view →
STAD	OS	Median	All	0.107	0.543	.011	24	view →
SARC	DFS	Median	All	0.101	0.632	.011	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →
COAD	OS	Median	II,III,IV	0.613	0.792	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WNT5A–UCEC (DFS)

Open the UCEC breakdown →