WNT5A

Across TCGA pan-cancer cohorts, WNT5A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of WNT5A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where WNT5A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WNT5A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, HNSC, and KIRP are the cancer types where WNT5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+1.546	<.001	11	view →
HNSC	Male	All	+1.018	<.001	10	view →
KIRP	All	All	+0.923	.001	8	view →
THCA	Male	All	+0.813	<.001	7	view →
KIRC	All	II,III,IV	−0.794	<.001	7	view →
KICH	Female	All	−1.550	<.001	5	view →
STAD	All	All	+0.930	.009	5	view →
LUSC	Male	II,III,IV	+1.876	<.001	4	view →
BRCA	All	II,III,IV	+0.523	.002	4	view →
READ	All	All	+1.479	.003	3	view →
LIHC	All	All	+0.512	.008	2	view →
BLCA	Male	III,IV	+2.665	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

WNT5A–COAD

Open the COAD breakdown →