WNT5A

Across TCGA pan-cancer cohorts, WNT5A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WNT5A data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WNT5A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WNT5A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, GBM, and LUAD are the cancer types where WNT5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	1.000	0.925	.020	12	view →
GBM	DFS	Median	All	0.228	0.463	.006	9	view →
LUAD	DFS	Median	II,III,IV	0.264	0.765	.019	8	view →
PDAC	DFS	Quartile	All	0.278	0.607	.009	7	view →
LSCC	DFS	Median	III,IV	0.894	0.464	.020	7	view →
UCEC	OS	Median	All	0.867	0.980	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WNT5A–HNSC (DFS)

Open the HNSC breakdown →