WNT5A

Across TCGA patient cohorts, WNT5A mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT5A-associated genes across cancer lineages are ASNS, JNK_pT183_Y185, and Notch1. Each is linked with WNT5A in more than 2 cancer types. Because this analysis shows association rather than direction, both WNT5A-to-partner and partner-to-WNT5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by WNT5A-low versus WNT5A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT5A→partner) and Y-score (partner→WNT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.737	+3.169	<.001	.018	3	3
COAD	JNK_pT183_Y185 →	-0.332	-2.321	.004	.033	3	2
COAD	Notch1 →	+0.184	+3.467	.028	.002	3	2
UCEC	PDCD4 →	-0.464	-1.504	.001	.014	3	2
COAD	C-Raf →	+0.171	+2.841	.009	.033	3	2
UCEC	EGFR_pY1068 →	-0.181	-1.415	.019	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASNS by WNT5A expression — COAD

Explore this box plot interactively →