WNT5A

Across TCGA cell cohorts, WNT5A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,014 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WNT5A-associated GO terms across cancer lineages are Melanocyte proliferation, Primary heart field specification, and Regulation of protein kinase C activity. Each is linked with WNT5A in more than 16 cancer types. Because this analysis shows association rather than direction, both WNT5A-to-partner and partner-to-WNT5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanocyte proliferation grouped by WNT5A-low versus WNT5A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT5A→partner) and Y-score (partner→WNT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Melanocyte proliferation →	+1.860	+4.069	<.001	<.001	3	17
STOMACH	Primary heart field specification →	+1.540	+2.899	<.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of protein kinase C activity →	+1.267	+2.674	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein kinase C activity →	+1.267	+2.674	<.001	.001	3	13
LIVER	Serotonergic neuron axon guidance →	+1.264	+2.692	<.001	.002	3	13
LIVER	Chemoattraction of axon →	+1.711	+3.861	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,014 associations by consensus.

Melanocyte proliferation by WNT5A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →