WNT5A

Across TCGA cell cohorts, WNT5A mutation is significantly associated with the RNA expression of many other genes, with 590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNT5A-associated genes across cancer lineages are LRP5L, SGSM3, and L3MBTL2. Each is linked with WNT5A in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT5A-to-partner and partner-to-WNT5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRP5L grouped by WNT5A-low versus WNT5A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT5A→partner) and Y-score (partner→WNT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRP5L →	+0.739	+3.364	.006	.002	3	1
LARGE_INTESTINE	SGSM3 →	+0.798	+3.364	<.001	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.716	+3.364	<.001	.002	3	1
LARGE_INTESTINE	USP14 →	+0.705	+3.451	.001	.002	3	1
LARGE_INTESTINE	FZD3 →	+0.843	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CYP3A5 →	-1.838	-3.169	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 590 associations by consensus.

LRP5L by WNT5A expression — LARGE_INTESTINE

Explore this box plot interactively →