WNT4

Across TCGA patient cohorts, WNT4 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT4-associated genes across cancer lineages are Caspase-7-cleavedD198, p70-S6K, and JNK_pT183_Y185. Each is linked with WNT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT4-to-partner and partner-to-WNT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by WNT4-low versus WNT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT4→partner) and Y-score (partner→WNT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.863	+3.169	.007	.020	3	1
UCEC	p70-S6K →	+0.233	+3.196	.027	.010	2	1
UCEC	JNK_pT183_Y185 →	-0.218	-3.156	.018	.020	1	1
UCEC	c-Kit →	-0.254	-3.169	.047	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Caspase-7-cleavedD198 by WNT4 expression — UCEC

Explore this box plot interactively →