WNT4

Across TCGA pan-cancer cohorts, WNT4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated WNT4 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher WNT4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WNT4 expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

KIRP, ACC, and SCLC are the cancer types where WNT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.782	0.921	<.001	95	view →
ACC	OS	Median	All	0.420	0.814	<.001	53	view →
SCLC	OS	Quartile	III,IV	0.848	0.476	.003	33	view →
PAAD	DFS	Median	All	0.381	0.179	<.001	29	view →
UCS	DFS	Median	II,III,IV	0.534	0.184	.004	28	view →
SARC	DFS	Median	All	0.713	0.505	<.001	25	view →
KIRC	DFS	Median	All	0.765	0.838	.016	24	view →
READ	OS	Median	II,III,IV	1.000	0.824	.016	19	view →
HNSC	DFS	Quartile	All	0.519	0.209	.009	19	view →
LUSC	OS	Median	IV	0.255	0.851	.021	6	view →
ESCA	DFS	Median	All	0.252	0.397	.038	6	view →
SKCM	OS	Median	III,IV	0.746	0.877	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

WNT4–KIRP (DFS)

Open the KIRP breakdown →