WNT4

Across TCGA cell cohorts, WNT4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,508 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible WNT4-associated GO terms across cancer lineages are Positive regulation of dermatome development, Negative regulation of testosterone biosynthetic process, and Regulation of dermatome development. Each is linked with WNT4 in more than 19 cancer types. Because this analysis shows association rather than direction, both WNT4-to-partner and partner-to-WNT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of dermatome development grouped by WNT4-low versus WNT4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT4→partner) and Y-score (partner→WNT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of dermatome development →	+1.422	+2.071	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Negative regulation of testosterone biosynthetic process →	-0.340	-1.364	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of dermatome development →	+1.495	+2.071	<.001	<.001	3	13
BREAST	Metanephric mesenchymal cell differentiation →	-0.283	-1.187	<.001	<.001	3	12
PANCREAS	Mesenchymal cell differentiation involved in kidney development →	-0.221	-0.727	.002	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of glucocorticoid biosynthetic process →	+1.549	+2.235	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,508 associations by consensus.

Positive regulation of dermatome development by WNT4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →