WNT4

Across TCGA cell cohorts, WNT4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WNT4-associated genes across cancer lineages are RIT2, PABPC1L2A, and OR10W1. Each is linked with WNT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT4-to-partner and partner-to-WNT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIT2 grouped by WNT4-low versus WNT4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT4→partner) and Y-score (partner→WNT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RIT2 →	+0.040	+6.022	<.001	.001	3	1
SKIN	PABPC1L2A →	+0.047	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+4.977	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

RIT2 by WNT4 expression — SKIN

Explore this box plot interactively →