WNT3A

Across TCGA pan-cancer cohorts, WNT3A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WNT3A data layer compared with 23 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher WNT3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WNT3A expression acts as an unfavorable survival marker.

LUAD, SKCM, and UCEC are the cancer types where WNT3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.223	0.677	.006	12	view →
SKCM	DFS	Median	All	0.063	0.757	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WNT3A–LUAD (OS)

Open the LUAD breakdown →