WNT3A

Across TCGA pan-cancer cohorts, WNT3A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of WNT3A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where WNT3A RNA is repressed in tumor relative to normal tissue. In most cancer types WNT3A is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

LUAD, KIRC, and LUSC are the cancer types where WNT3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−3.565	<.001	9	view →
KIRC	All	II,III,IV	−0.105	.001	8	view →
LUSC	All	II,III,IV	−2.056	<.001	7	view →
KICH	All	All	−0.255	<.001	7	view →
HNSC	Male	All	+1.088	<.001	6	view →
COAD	All	All	+0.053	.001	6	view →
LIHC	All	All	+0.624	.004	5	view →
PAAD	Male	All	+0.795	.042	4	view →
UCEC	All	All	+0.843	.005	2	view →
PRAD	All	All	−0.764	<.001	2	view →
CHOL	All	All	+0.385	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

WNT3A–LUAD

Open the LUAD breakdown →