WNT3A

Across TCGA patient cohorts, WNT3A mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT3A-associated genes across cancer lineages are Rictor_pT1135, Shc_pY317, and c-Jun_pS73. Each is linked with WNT3A in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT3A-to-partner and partner-to-WNT3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by WNT3A-low versus WNT3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT3A→partner) and Y-score (partner→WNT3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.111	-2.000	.007	.029	3	2
UCEC	Shc_pY317 →	-0.121	-2.000	.047	.030	3	2
UCEC	c-Jun_pS73 →	-0.141	-2.986	.027	.035	3	2
SKCM	PARP_cleaved →	+0.161	+3.000	.031	.035	3	1
UCEC	ER-alpha_pS118 →	-0.330	-1.906	.022	.016	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.321	.005	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Rictor_pT1135 by WNT3A expression — UCEC

Explore this box plot interactively →