WNT3A

Across TCGA cell cohorts, WNT3A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WNT3A-associated genes across cancer lineages are RNASE11, KRTAP4-11, and KRTAP10-10. Each is linked with WNT3A in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT3A-to-partner and partner-to-WNT3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE11 grouped by WNT3A-low versus WNT3A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT3A→partner) and Y-score (partner→WNT3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RNASE11 →	+0.038	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP4-11 →	+0.012	+5.539	.004	.003	3	1
BLOOD_Leukemia	KRTAP10-10 →	+0.038	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP10-11 →	+0.028	+5.539	<.001	.003	3	1
SKIN	HTR1E →	+0.036	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CPLX4 →	+0.048	+4.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

RNASE11 by WNT3A expression — BLOOD_Leukemia

Explore this box plot interactively →