WNT2

Across TCGA pan-cancer cohorts, WNT2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated WNT2 data layer compared with 17 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher WNT2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WNT2 expression acts as an unfavorable survival marker.

LUAD and PDAC are the cancer types where WNT2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.900	1.000	.007	12	view →
PDAC	DFS	Median	IV	0.250	0.741	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

WNT2–LUAD (OS)

Open the LUAD breakdown →