WNT16

Across TCGA patient cohorts, WNT16 mutation is significantly associated with the RNA expression of many other genes, with 731 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT16-associated genes across cancer lineages are DHRS11, NUP35P2, and AKR1A1. Each is linked with WNT16 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT16-to-partner and partner-to-WNT16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHRS11 grouped by WNT16-low versus WNT16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT16→partner) and Y-score (partner→WNT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHRS11 →	+0.775	+2.601	<.001	.006	3	2
BLCA	NUP35P2 →	+0.030	+4.562	<.001	.006	3	2
UCEC	AKR1A1 →	+0.490	+3.906	<.001	<.001	3	2
UCEC	RPUSD2 →	+0.410	+3.507	.003	.002	3	2
UCEC	THOP1 →	+0.758	+3.743	<.001	<.001	3	2
UCEC	RNH1 →	+0.533	+2.807	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

DHRS11 by WNT16 expression — UCEC

Explore this box plot interactively →