WNT16

Across TCGA pan-cancer cohorts, WNT16 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of WNT16’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where WNT16 RNA is repressed in tumor relative to normal tissue. In most cancer types WNT16 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and LUSC are the cancer types where WNT16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−0.224	<.001	8	view →
KIRC	Male	All	−0.071	<.001	6	view →
LUSC	Male	All	+0.828	<.001	4	view →
READ	All	All	−0.511	.017	4	view →
COAD	Male	All	−0.234	.030	3	view →
PRAD	All	All	−0.396	<.001	2	view →
LUAD	All	All	+0.198	.006	2	view →
LUSC	Female	III,IV	−0.489	.002	1	view →
KICH	Female	II,III,IV	−0.101	.005	1	view →
ESCA	Female	All	+0.093	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

WNT16–KIRP

Open the KIRP breakdown →