WNT16

Across TCGA patient cohorts, WNT16 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT16-associated genes across cancer lineages are ATM, Caspase-8, and MSH2. Each is linked with WNT16 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT16-to-partner and partner-to-WNT16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by WNT16-low versus WNT16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT16→partner) and Y-score (partner→WNT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.641	-2.459	.003	.020	3	1
UCEC	Caspase-8 →	-0.264	-2.459	.029	.020	3	1
UCEC	MSH2 →	-0.265	-3.160	.017	.019	2	1
UCEC	p62 Lck ligand →	+0.373	+2.459	.017	.020	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ATM by WNT16 expression — UCEC

Explore this box plot interactively →