WNT16

Across TCGA cell cohorts, WNT16 mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNT16-associated genes across cancer lineages are ZBED4, DDHD1, and KRI1. Each is linked with WNT16 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT16-to-partner and partner-to-WNT16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBED4 grouped by WNT16-low versus WNT16-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT16→partner) and Y-score (partner→WNT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZBED4 →	+0.578	+3.364	.002	.002	3	2
LARGE_INTESTINE	DDHD1 →	+0.829	+3.364	<.001	.002	3	2
LARGE_INTESTINE	KRI1 →	+0.645	+3.364	.002	.002	3	2
LARGE_INTESTINE	GATAD2B →	+0.564	+3.364	.002	.002	3	2
LARGE_INTESTINE	FBXL14 →	+0.633	+3.364	.008	.002	3	2
LARGE_INTESTINE	ZNF852 →	+0.701	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

ZBED4 by WNT16 expression — LARGE_INTESTINE

Explore this box plot interactively →