WNK4

Across TCGA patient cohorts, WNK4 mutation is significantly associated with the RNA expression of many other genes, with 4,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNK4-associated genes across cancer lineages are SKA1, CCNB2, and RCCD1. Each is linked with WNK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both WNK4-to-partner and partner-to-WNK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by WNK4-low versus WNK4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK4→partner) and Y-score (partner→WNK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SKA1 →	+0.767	+3.472	.001	.002	3	4
UCEC	CCNB2 →	+0.591	+1.754	.001	.001	3	4
UCEC	RCCD1 →	+0.377	+2.021	<.001	<.001	3	4
STAD	PBK →	+1.039	+2.597	<.001	.005	3	4
SKCM	CKAP2L →	+0.631	+1.722	.001	.002	3	4
UCEC	RRM2 →	+0.700	+1.754	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,130 associations by consensus.

SKA1 by WNK4 expression — STAD

Explore this box plot interactively →