WNK4

Across TCGA patient cohorts, WNK4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNK4-associated genes across cancer lineages are ASNS, Bap1-c-4, and Cyclin-B1. Each is linked with WNK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both WNK4-to-partner and partner-to-WNK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by WNK4-low versus WNK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK4→partner) and Y-score (partner→WNK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.356	+1.678	.003	.021	3	4
STAD	Bap1-c-4 →	+0.498	+3.321	.002	.009	3	3
UCEC	Cyclin-B1 →	+0.459	+2.115	.016	.017	3	3
STAD	eIF4G →	+0.493	+2.321	.037	.034	3	2
STAD	B-Raf →	+0.366	+3.031	.021	.017	3	2
COAD	eEF2 →	+0.548	+2.815	<.001	.036	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ASNS by WNK4 expression — UCEC

Explore this box plot interactively →