WNK4

Across TCGA cell cohorts, WNK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,497 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNK4-associated GO terms across cancer lineages are Corticosteroid hormone secretion, Protein polyglycylation, and Steroid hormone secretion. Each is linked with WNK4 in more than 12 cancer types. Because this analysis shows association rather than direction, both WNK4-to-partner and partner-to-WNK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Corticosteroid hormone secretion grouped by WNK4-low versus WNK4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK4→partner) and Y-score (partner→WNK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Corticosteroid hormone secretion →	+1.363	+2.521	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Protein polyglycylation →	+0.840	+0.691	.002	.001	3	9
SOFT_TISSUE	Steroid hormone secretion →	+1.271	+1.742	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to vacuole →	+0.105	+1.001	<.001	.001	3	8
BLOOD_Leukemia	Glycerophospholipid biosynthetic process →	+0.022	+0.573	<.001	.003	3	8
LUNG_NSCLC_LUAD	Lipid export from cell →	-0.219	-0.781	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,497 associations by consensus.

Corticosteroid hormone secretion by WNK4 expression — URINARY_TRACT

Explore this box plot interactively →