WNK2

Across TCGA cell cohorts, WNK2 mutation is significantly associated with the RNA expression of many other genes, with 1,459 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNK2-associated genes across cancer lineages are NOA1, ABCA2, and POLR1B. Each is linked with WNK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both WNK2-to-partner and partner-to-WNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOA1 grouped by WNK2-low versus WNK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK2→partner) and Y-score (partner→WNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NOA1 →	+0.546	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	ABCA2 →	+0.705	+1.808	.004	.001	3	3
LARGE_INTESTINE	POLR1B →	+0.491	+3.321	<.001	.002	3	3
LARGE_INTESTINE	PARN →	+0.509	+2.212	<.001	<.001	3	2
SKIN	TOMM70 →	+0.429	+3.212	.001	.006	3	2
SKIN	PARP3 →	+0.727	+3.299	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,459 associations by consensus.

NOA1 by WNK2 expression — LARGE_INTESTINE

Explore this box plot interactively →