WNK1

Across TCGA pan-cancer cohorts, WNK1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated WNK1 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher WNK1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated WNK1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, UCEC, and SKCM are the cancer types where WNK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	II,III,IV	0.947	0.607	.004	33	view →
UCEC	DFS	Median	All	0.742	0.632	.022	10	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	9	view →
LUAD	OS	Median	II,III,IV	0.810	0.187	.012	8	view →
KIRC	DFS	Median	All	0.127	0.865	<.001	6	view →
LGG	OS	Median	All	0.454	0.912	.002	6	view →
STAD	OS	Median	IV	0.771	0.288	.036	3	view →
HNSC	OS	Median	All	0.282	0.610	.038	3	view →
LIHC	OS	Median	All	0.254	0.708	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

WNK1–BLCA (DFS)

Open the BLCA breakdown →