WNK1

Across TCGA pan-cancer cohorts, WNK1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of WNK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WNK1 RNA is repressed in tumor relative to normal tissue. In most cancer types WNK1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where WNK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.138	<.001	12	view →
HNSC	All	II,III,IV	+0.626	<.001	9	view →
LIHC	Female	II,III,IV	+1.004	<.001	8	view →
KIRP	Male	All	−1.428	<.001	7	view →
CHOL	Male	All	+1.759	<.001	5	view →
BRCA	All	II,III,IV	+0.346	<.001	4	view →
KICH	All	All	−0.680	.010	2	view →
UCEC	All	All	−0.520	.015	2	view →
LUAD	All	All	−0.277	.023	1	view →
THCA	All	All	−0.249	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

WNK1–KIRC

Open the KIRC breakdown →