WNK1

Across TCGA pan-cancer cohorts, WNK1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated WNK1 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher WNK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WNK1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where WNK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.870	1.000	.012	48	view →
LUAD	OS	Median	All	1.000	0.769	.005	9	view →
CCRCC	OS	Quartile	III,IV	0.510	0.846	.026	5	view →
UCEC	DFS	Quartile	III,IV	1.000	0.451	.040	4	view →
PDAC	DFS	Tertile	IV	0.203	0.741	.024	3	view →
GBM	OS	Tertile	All	0.257	0.606	.029	2	view →
LSCC	DFS	Quartile	All	1.000	0.907	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

WNK1–COAD (DFS)

Open the COAD breakdown →