WNK1

Across TCGA patient cohorts, WNK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,092 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible WNK1-associated proteins across cancer lineages are DNM1L, USP5, and WNK1_S2027. Each is linked with WNK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both WNK1-to-partner and partner-to-WNK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WNK1 versus DNM1L in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK1→partner) and Y-score (partner→WNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DNM1L →	+0.330	+0.301	<.001	.004	3	6
HNSC	USP5 →	+0.365	+0.678	<.001	<.001	3	5
HNSC	WNK1_S2027 →	+0.441	+0.589	<.001	<.001	3	4
HNSC	WNK1_S2279 →	+0.441	+0.589	<.001	<.001	3	4
LSCC	PHB →	+0.391	+0.459	<.001	<.001	3	4
LUAD	CAPN5 →	-0.460	-0.531	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,092 associations by consensus.

WNK1 vs DNM1L — GBM

Explore this scatter interactively →