WNK1

Across TCGA patient cohorts, WNK1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,309 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible WNK1-associated genes across cancer lineages are NINJ2-AS1, NINJ2, and C12orf4. Each is linked with WNK1 in more than 6 cancer types. Because this analysis shows association rather than direction, both WNK1-to-partner and partner-to-WNK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WNK1 versus NINJ2-AS1 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK1→partner) and Y-score (partner→WNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NINJ2-AS1 →	+0.874	+0.348	<.001	<.001	3	7
LUAD	NINJ2 →	+0.904	+0.268	<.001	<.001	3	5
OV	C12orf4 →	+0.570	+0.292	<.001	<.001	3	5
OV	COPS7A →	+0.573	+0.339	.001	<.001	3	5
BRCA	ADIPOR2 →	+0.550	+0.255	<.001	<.001	3	5
COAD	CLEC2B →	+0.832	+0.181	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,309 associations by consensus.

WNK1 vs NINJ2-AS1 — BRCA

Explore this scatter interactively →